MCED Patents


Following an exhaustive (and crushingly expensive for the applicant), 8 year review process by the U.S. patent office, Dr. Weisenthal finally was awarded patents on virtually all aspects of MCED, including pharmacodiagnostic tests he developed which detect its presence in individuals. The interventional target itself is also patented, affording protection to biopharmaceutical partners wishing to develop MCED-targeted drug therapies.


The following are U.S. patents.  This is of great importance to potential collaborators seeking to commercialize the work.  Historically, commercialization has been the fastest means of bringing the benefits of new medical discoveries to the public.


  1. 1.Method to detect endothelial cell massive calcium accumulation death

Patent number: 8623613

Abstract: Stains that are specific for calcium ion are used to assess and predict the effects of various treatments on the viability of cell types contained in a sample, wherein said stain detects endothelial cells that have massive calcium accumulation death.

Type: Granted

Filed: April 13, 2011

Issued: January 7, 2014

Inventor: Larry M. Weisenthal

Link to patent online:

http://www.google.com/patents/US8623613

  1. 2.Efficient well being assessment and improved treatment protocol

Abstract: Methods to appraise general health and to assess the effectiveness of therapeutic agents are disclosed. These methods can be performed on blood samples or other bodily fluids and comprise effecting cell death of endothelial cells, staining the dead cells and observing them microscopically. In addition, the invention is directed to combination treatments for neoplastic diseases or other conditions characterized by unwanted angiogenesis by administering an antiangiogenesis agent while maintaining nontoxic levels of ethanol and/or DMSO in the blood.

Type: Granted

Filed: May 22, 2009

Issued: October 2, 2012

Inventor: Larry M. Weisenthal

Link to patent online:

http://www.google.com/patents/US8278033

  1. 3.Microaggregates including endothelial cells

Patent number: 8192949

Abstract: Microaggregates which mimic the native environment of cells contained in biopsied tissue are used to assess and predict the effects of various treatments on the viability of cell types contained in the microaggregate.

Type: Granted

Filed: December 15, 2006

Issued: June 5, 2012

Inventor: Larry M. Weisenthal

Link to patent Online:

http://www.google.com/patents/US8192949


Three additional U.S. patent applications have been filed are pending.



New Discoveries in Cancer and Heart Disease

“I am replying myself, because I can no longer afford the extensive legal fees I have incurred in pursuing this patent application. I am not a lawyer, and doubtless I

will not utilize proper terminology.  I hope that you will

pardon my lack of  legal know-how.”