New Discoveries in Cancer and Heart Disease

“The way to prevent heart disease will not be to lower serum lipid levels but instead to block the MCED cascade.”



“This approach will result in the discovery of an entirely new class of drugs for prevention and cure of heart disease.”

MCAD Publications



  1. 1.Weisenthal, L. M. Patel,N., Rueff-Weisenthal, C. (2008). "Cell culture detection of microvascular cell death in clinical specimens of human neoplasms and peripheral blood." J Intern Med 264(3): 275-287. 

  2. 2.Weisenthal, L., Lee,DJ, and Patel,N. (2008). Antivascular activity of lapatinib and bevacizumab in primary microcluster cultures of breast cancer and other human neoplasms. ASCO 2008 Breast Cancer Symposium. Washington, D.C.: Abstract # 166. Slide presentation at: http://tinyurl.com/weisenthal-breast-lapatinib 

  3. 3.Weisenthal, L. M. (2010). Antitumor and anti-microvascular effects of sorafenib in fresh human tumor culture in comparison with other putative tyrosine kinase inhibitors.  J Clin Oncol 28, 2010 (suppl; abstr e13617) 

  4. 4.Weisenthal, L., H. Liu, Rueff-Weisenthal, C. (2010). Death of human tumor endothelial cells in vitro through a probable calcium-associated mechanism induced by bevacizumab and detected via a novel method. Nature Precedings 28 May 2010. http://precedings.nature.com/documents/4499/version/1 

  5. 5.Weisenthal, Larry . Endothelial Massive Calcium Accumulation Death (MCAD): Mechanism, Target, and Predictive Biomarker for Anti-Angiogenic Therapy. 13th international symposium on anti-angiogenic therapy: recent advances  and future directions in basic and clinical cancer research. LaJolla, CA. Feb 2011 Nature Precedings  http://dx.doi.org/10.1038/npre.2011.6647.1  

  6. 6.Weisenthal, L, Williamson, S, Ryan, K, Brunshwiler, C, and Rueff-Weisenthal, C. Massive calcium uptake in human endothelial cells, submitted for publication. 

  7. 7.Bevacizumab-induced tumor calcifications can be elicited in glioblastoma microspheroid culture and represent massive calcium uptake death (MCAD) of tumor endothelial cells. Larry Weisenthal, Summer Williamson, Cindy Brunschwiler, and Constance Rueff-Weisenthal, 14th International Anti-Angiogenesis Symposium, LaJolla CA, Feb 2012. Available from Nature Precedings  http://dx.doi.org/10.1038/npre.2012.7069.1  (2012)